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FLASH GENE
Symbol SLC22A4 contributors: shn - updated : 13-01-2009
HGNC name solute carrier family 22 (organic cation/ergothioneine transporter), member 4
HGNC id 10968
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
  • a SNP affects the transcriptional efficiency of SLC22A4 in vitro, owing to an allelic difference in affinity to Runt-related transcription factor-1 (RUNX1; 151385), a transcriptional regulator in the hematopoietic system. A SNP in RUNX1 (151385.0007) was also strongly associated with rheumatoid arthritis
  • regulation of SLC22A4 expression by RUNX1 is associated with susceptibility to rheumatoid arthritis
  • to Crohn disease (see IBD5)
  • Variant & Polymorphism SNP , other a missense substitution increasing the susceptibility to Crohn disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS