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FLASH GENE
Symbol PROZ contributors: mct - updated : 25-05-2011
HGNC name protein Z, vitamin K-dependent plasma glycoprotein
HGNC id 9460
ASSOCIATED DISORDERS
corresponding disease(s) PROZ
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
is a risk factor for retinal vessel occlusion
constitutional     --low  
associated with an increased risk of thrombosis
constitutional     --low  
in chronic kidney disease
constitutional        
high rate of protein Z deficiency is observed in patients with preeclampsia and fetal demise (
Susceptibility
  • to recurrent early pregnancy loss (RPL)
  • to premature myocardial infarction (Minor role) (
  • Variant & Polymorphism other
  • isolated presence of the intron F 79A allele as well as the combination with known thrombophilic risk factors was protective against RPL between the 8th and 12th weeks of gestation
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS