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FLASH GENE
Symbol ENTPD5 contributors: mct - updated : 06-07-2011
HGNC name ectonucleoside triphosphate diphosphohydrolase 5
HGNC id 3367
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in human prostatic intraepithelial neoplasia , detectable in benign prostatic hyperplasia, highly expressed in prostatic intraepithelial neoplasia, and remaining at high levels in prostate carcinoma
  • Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • good early molecular marker for testicular neoplasms, and immunodetection of truncated ENTPD5 polypeptides may be a useful diagnostic tool for testicular germ cell tumors
  • altered ENTPD5 polypeptides by Western analysis potentially can be applied to the early identification of laryngeal squamous cell carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential target for anticancer therapy
    cancer  
    developing ENTPD5 inhibitors for cancer therapy may be a worthwhile pursuit
    ANIMAL & CELL MODELS
  • nactivation of Entpd5 in mice (Entpd5(-/-)) resulted in 2 major histopathologic lesions: hepatopathy and aspermia