Symbol
| ENTPD5
| contributors: mct - updated : 06-07-2011
|
HGNC name
| ectonucleoside triphosphate diphosphohydrolase 5
|
HGNC id
| 3367
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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tumoral
|  
|  
| --over
|  
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in human prostatic intraepithelial neoplasia , detectable in benign prostatic hyperplasia, highly expressed in prostatic intraepithelial neoplasia, and remaining at high levels in prostate carcinoma | |
Variant & Polymorphism
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| |
Candidate gene
Marker
| good early molecular marker for testicular neoplasms, and immunodetection of truncated ENTPD5 polypeptides may be a useful diagnostic tool for testicular germ cell tumors | |
altered ENTPD5 polypeptides by Western analysis potentially can be applied to the early identification of laryngeal squamous cell carcinoma | Therapy target
|
System | Type | Disorder | Pubmed |
cancer | | | |
potential target for anticancer therapy | cancer | | | |
developing ENTPD5 inhibitors for cancer therapy may be a worthwhile pursuit |
| | |
| nactivation of Entpd5 in mice (Entpd5(-/-)) resulted in 2 major histopathologic lesions: hepatopathy and aspermia |