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FLASH GENE
Symbol ILK contributors: mct/pgu - updated : 07-01-2016
HGNC name integrin-linked kinase
HGNC id 6040
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
2 novel amino acid residue-altering mutations (2828C>T [Pro943Leu] and 3217C>T [Arg1073X]) in the integrin-interacting domain of the LAMA4 gene and 1 mutation (785C>T [Ala262Val]) in the ILK gene in dilated cardiomyopathy
tumoral     --over  
in various tumors independent of TGF-beta 1
tumoral     --over  
during liver oncogenesis and cirrhosis correlates with activation of Akt but not with other conventional ILK targets
tumoral     --over  
is associated with tumor progression and a poor (CRC)prognosis in colorectal patients
tumoral     --over  
promotes cellular transformation, cell survival, epithelial mesenchymal transition (EMT), and metastasis of hormonal cancer cells while inhibition of ILK1 reduces tumor growth and progression
Susceptibility
Variant & Polymorphism
Candidate gene
Marker may represent a novel potential prognostic marker for patients with CRC
Therapy target
SystemTypeDisorderPubmed
cancer  
potential role therapeutic of the anti-mitotic effects of genetic or pharmacological inhibition of ILK
cancer  
inhibiting ILK offers a selective means of targeting cancer cells
cancerreproductiveovary
targeting ILK and ITGB4 abrogates the invasive potential of ovarian cancer
cancerurinary 
could be served as a novel potential therapy target for human bladder cancer
ANIMAL & CELL MODELS