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FLASH GENE
Symbol WHSC1 contributors: mct/pgu - updated : 18-02-2012
HGNC name Wolf-Hirschhorn syndrome candidate 1
HGNC id 12766
ASSOCIATED DISORDERS
corresponding disease(s) WHS , WHSCR
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
fused to IgH in multiple myeloma with translocation t(4;14)((p16.3;q32) with FGFR3 overexpression
tumoral     --over  
in multiple myeloma with poor prognosis, in patients with the translocation t(4;14)
tumoral somatic mutation      
in acute myeloid leukemia
tumoral     --other  
aberrant expression in glioblastoma multiform
constitutional     --low  
resulted in cellular hypersensitivity to ionizing radiation
tumoral     --over  
in neuroblastoma
Susceptibility
Variant & Polymorphism
Candidate gene Wolf-Hirschhorn syndrome candidate gene 1
Marker
Therapy target
SystemTypeDisorderPubmed
cancerbrainglioma/neuroblstoma
might be a strong candidate therapeutic target in a subset of neuroblastomas with unfavorable prognosis
ANIMAL & CELL MODELS