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FLASH GENE
Symbol HCRTR1 contributors: mct - updated : 07-07-2020
HGNC name hypocretin (orexin) receptor 1
HGNC id 4848
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
HCRTR1 blockade suppresses endogenous phasic dopamine signals, likely via actions at dopamine cell bodies
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
miscelleaneoussleep 
in contrast to GABA receptor agonists which induce sleep by generalized inhibition, HCRTR1 antagonists seem to facilitate sleep by reducing waking "drive"
ANIMAL & CELL MODELS
  • Ox1r(-/-) mice showed impaired freezing responses in both cued and contextual fear-conditioning paradigms