Symbol
| HCRTR1
| contributors: mct - updated : 07-07-2020
|
HGNC name
| hypocretin (orexin) receptor 1
|
HGNC id
| 4848
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --low
|  
|
HCRTR1 blockade suppresses endogenous phasic dopamine signals, likely via actions at dopamine cell bodies  | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
miscelleaneous | sleep | |  |
in contrast to GABA receptor agonists which induce sleep by generalized inhibition, HCRTR1 antagonists seem to facilitate sleep by reducing waking "drive" |
| | | |
| Ox1r(-/-) mice showed impaired freezing responses in both cued and contextual fear-conditioning paradigms  |