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FLASH GENE
Symbol ERCC4 contributors: mct/npt - updated : 06-06-2016
HGNC name excision repair cross-complementing rodent repair deficiency, complementation group 4
HGNC id 3436
ASSOCIATED DISORDERS
corresponding disease(s) XPF , XFEP , FANCQ
Susceptibility
  • to lung cancer
  • to cutaneous melanoma
  • to squamous cell carcinoma of the head and neck (SCCHN)
  • Variant & Polymorphism other
  • polymorphism rs3136038 on the promotor region of ERCC4 may contribute to the etiology of lung cancer (Shao 2008)
  • significant associations with the strongest associations for melanoma cases aged 50 and under (POvey 2007)
  • two SNPs (rs2276466 and rs3136038) in ERCC4 may be functional and contribute to SCCHN susceptibility
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS