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FLASH GENE
Symbol LSAMP contributors: mct/npt - updated : 09-06-2020
HGNC name limbic system-associated membrane protein
HGNC id 6705
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   LOH    
in osteosarcoma (Yen 2009)
tumoral   deletion    
in osteosarcomas (Kresse 2009)
tumoral     --over  
of the LSAMP and TUSC7 genes in acute myeloid leukemia
Susceptibility
  • to late-onset coronary artery disease (CAD)
  • to ulcerative colitis (UC)
  • to schizophrenia
  • Variant & Polymorphism SNP
  • increasing the risk of late-onset coronary artery disease (CAD)(Wang 2008)
  • SNPs at ZNF649 and LSAMP, with associations of genome-wide significance for UC
  • significant allelic and haplotypic associations between LSAMP gene and schizophrenia
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS