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FLASH GENE
Symbol ERBB2 contributors: mct - updated : 05-03-2019
HGNC name v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
HGNC id 3430
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in primary gastric cancer and prostate carcinoma with metastasis and poor prognosis, pancreas, colon and ovary carcinoma, cholangiocarcinoma
tumoral       gain of function
in primary breast and uterus endometrial cancer and in low grade osteosarcoma with increased survival
tumoral somatic mutation      
in dilated cardiomyopathy
tumoral     --over  
in neuro/glioblastoma and in non-small cell lung cancer
tumoral   amplification    
in many types of cancer, including breast cancer
tumoral somatic mutation      
in the lung squamous cell carcinoma (kinase domain mutation )
tumoral     --over  
in breast cancer cells with poor prognostic (with enhanced tumorigenicity, propensity to metastasize and resistance to endocrine therapy)
tumoral   amplification    
loss of beclin 1 and ERBB2 amplification (both on 17q21) in breast cancers
tumoral     --over  
patients breast cancer with higher CCNA2 and ERBB2 expressions had significantly shorter disease-free survival periods
tumoral   amplification    
may be involved in tumor progression in early gastric cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker overexpression in breast cancer cells are known to be poor prognostic markers and are strong predictors of benefit from treatment with ERBB2-targeting agents
Therapy target
SystemTypeDisorderPubmed
cancerreproductivebreast
selected RNA aptamer is a potential cancer imaging agent by targeting malignant cells of breast cancer overexpressing the ERBB2 receptor
cancerreproductivebreast
blockade of ERBB2:TGFB crosstalk may significantly enhance the efficiency of conventional therapies in breast cancer patients with ERBB2 overexpression
cancerreproductivebreast
anti-ERBB2 human compact antibody-RNase (Erb-hcAb-RNase) could be a promising candidate for the immunotherapy of ERBB2-positive tumours
cancerreproductivebreast
therapeutic inhibitors of ERBB3 should be used in combination with HER2 inhibitors and PI3K pathway inhibitors in patients with ERBB2- and PI3K-dependent cancers
cancerreproductivebreast
interactions between ATP2B2 and ERBB2 may represent therapeutic targets for breast cancer
cancerreproductivebreast
strategies to block ERBB2/BECN1 binding and/or increase autophagy may represent a new therapeutic approach for ERBB2-positive breast cancers (PMID: 29610308)
cancerreproductivebreast
interactions between ATP2B2 and ERBB2 may represent therapeutic targets for breast cancer
ANIMAL & CELL MODELS