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FLASH GENE
Symbol ENO2 contributors: mct - updated : 11-03-2020
HGNC name enolase 2, (gamma, neuronal)
HGNC id 3353
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
dramatically in cardiovascular accidents, cerebral trauma, brain tumors and creutzfeldt-jacob disease
constitutional     --over  
early elevations (up to 3 days) of S100B and ENO2 secondary to severe traumatic brain injury, predict deterioration to brain death, but more prominently associated with ENO2 than S100B
constitutional     --over  
in patients with migraine-without aura, increased ictal serum S100B and ENO2 levels together with increased interictal levels of S100B suggested that migraine might be associated with glial and/or neuronal damage in the brain and a prolonged disruption of blood-brain barrier
constitutional     --low  
associated with better neurologic outcomes of head trauma in children (
constitutional     --over  
in tic disorders (TD)
constitutional     --over  
in diabetic ketoacidosis and correlated with the severity of hyperglycemia, ketosis, and acidosis
constitutional     --over  
in asymptomatic carriers of Leber hereditary optic neuropathy (
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • increased serum GFAP, S100B, ENO2 are associated with acute CO poisoning, and these biomarkers can be useful in assessing the clinical status of patients with CO poisoning
  • ENO2 concentrations in older people may be a useful predictor of individuals at risk of more severe long-term cognitive decline
  • serum ENO2 levels are closely associated with peripheral neuropathy in patients with diabetes
  • may be likely a significant biomarker in Tics didorder
  • AVP and ENO2 measured in the early postnatal period are potential prognostic biomarkers of long-term neurodevelopmental outcome in term neonates diagnosed with hypoxic-ischemic encephalopathy (HIE) and treated with therapeutic hypothermia
  • Therapy target
    ANIMAL & CELL MODELS