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FLASH GENE
Symbol RAB13 contributors: mct - updated : 14-09-2022
HGNC name RAB13, member RAS oncogene family
HGNC id 9762
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --other  
present in apical tight junctions in normal epithelium but were dislocated to the basolateral position in patients with inactive Crohn disease (
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerreproductivebreast
Targeting Rab13 perturbs formation of the breast cancer stem cell niche by inhibiting cross-talk between cancer cells and the tumor microenvironment, providing a therapeutic opportunity for niche-targeted breast cancer treatment
cancer  
blocking RAB13 activation by ST5 may provide a novel target to limit the spread of epithelial cancers
ANIMAL & CELL MODELS