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FLASH GENE
Symbol SELE contributors: mct - updated : 03-01-2013
HGNC name selectin E (endothelial adhesion molecule 1)
HGNC id 10718
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
reduced leucocyte rolling velocity
constitutional     --over  
in patients with hereditary angioedema, during inter-attack periods
Susceptibility
  • to atherosclerosis
  • to essential hypertension
  • to pancreatic cancer development
  • Variant & Polymorphism other
  • mutations of the gene may be a risk factor in atherosclerosis
  • S128R "C" allele may confer an increased susceptibility to pancreatic cancer development
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS