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FLASH GENE
Symbol SLC22A1 contributors: mct/npt - updated : 09-11-2016
HGNC name solute carrier family 22 (organic cation transporter), member 1
HGNC id 10963
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
  • to genetic variation of metformin pharmacokinetics (Shu 2008)
  • variation in responses to imatinib in patients with chronic myeloid leukaemia
  • Variant & Polymorphism other
  • common novel splice variant of SLC22A1 is associated with impaired responses to imatinib in patients with chronic myeloid leukaemia
  • variants of SLC22A1, including p.Arg61Cys and p.Met420del variants, are known to impair metformin uptake
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS