Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
| LOH
|  
|  
|
in breast and ovarian carcinoma |
constitutional
|  
|  
| --over
|  
|
involved in reducing aggresome formation and Lewy bodies but can be dissociated from effect on neuronal survival |
tumoral
|  
|  
|  
|  
|
significantly associated with adenomatous polyposis coli (APC) deficiency in colorectal cancer |
tumoral
|  
|  
| --low
|  
|
dramatically down-regulated in a variety of breast cancer cell lines as well as in primary breast cancer tissues |
constitutional
|  
|  
| --other
|  
|
increased turnover of parkin may contribute to the pathogenesis of Machado-Joseph diseas and help explain some of its parkinsonian features ( |
constitutional
|  
|  
| --low
|  
|
in chronic obstructive pulmonary disease (COPD) lung, suggesting that insufficient mitophagy is a part of the pathogenic sequence of COPD |
tumoral
|  
|  
| --low
|  
|
crucial involvement of parkin deficiency in the pathogenesis of pancreatic cancer |
tumoral
|  
|  
| --low
|  
|
associated with high-grade clear-cell renal cell carcinomas (ccRCCs) and lymph node metastasis |