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FLASH GENE

Symbol

ANGPT1

contributors: mct/npt/pgu - updated : 22-12-2015

HGNC name	angiopoietin 1
HGNC id	484

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in hepatocellular carcinoma in progression and in synovial fibroblasts of rheumatoid arthritis (RA) constitutional     --low   in menorrhagia constitutional     --other   ectopic expression of Ang1 promotes neuronal differentiation and neurite outgrowth in neural progenitor cells constitutional     --over   in Behçet disease patients compared to controls

Susceptibility

to pregnancy complications

Variant & Polymorphism other	ANGPT1 rs2507800 polymorphism may have a potential role in screening women to predict the risk of these pregnancy complications

Candidate gene
Marker	a single measurement of serum ANGPT1 and ANGPT2 at 6-8 weeks of gestation designate the outcome of a pregnancy, as their levels are significantly decreased in failed than normal pregnancies
	serum ANGPT1 showed potential to discriminate missed abortions (MA) from ectopic pregnancies (EP)
Therapy target
	System Type Disorder Pubmed miscelleaneous vascular   candidate for therapeutic neovascularization and vascular protection

ANIMAL & CELL MODELS

	mice overexpressing Angpt1
	in mice variant COMP-Angpt1 ameliorates leukocyte adhesion and reinforces endothelial tight junctions during endotoxemia