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FLASH GENE
Symbol KLK10 contributors: mct - updated : 08-04-2020
HGNC name kallikrein-related peptidase 10
HGNC id 6358
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in ovarian, colorectal and gastric cancer and higher expression of KLK10 closely correlates with advanced disease stage, which predicts a poorer prognosis
tumoral     --low  
in breast cancer (in progression), and in testicular cancer, in cervical cancer, prostate cancer and acute lymphocytic leukemia
tumoral     --over  
in oral squamous cell carcinoma and may be implicated in malignant progression
tumoral     --low  
in hepatocellular carcinoma by hypermethylation, significantly associated with cirrhosis and HCV infection as well as inversely associated with HBV infection
constitutional     --over  
significantly increased in Alzheimer disease
tumoral     --over  
increased KLK10 and KLK11 protein expression is associated with favorable prognosis in advanced high-grade serous ovarian cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • potential biomarker in colon adenocarcinoma
  • promising biomarker for diagnosis in Pancreatic Ductal Adenocarcinoma (PADC)
  • KLK6 and KLK10 may be useful markers in gastroesophageal junction tumors
  • Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    potential target for therapy in Pancreatic Ductal Adenocarcinoma (PADC)
    cancerdigestiveoesophagus
    potential therapeutic targets in gastroesophageal junction tumors
    ANIMAL & CELL MODELS