Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SUPV3L1

contributors: mct/pgu - updated : 02-02-2013

HGNC name	suppressor of var1, 3-like 1 (S. cerevisiae)
HGNC id	11471

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   exhibited an up-regulation of TP53, mediating activation of CDKN1A, which has been shown to be the major regulator of the cellular senescence program constitutional       loss of function leads to accelerated aging-like phenotypes

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     maintaining mtDNA integrity by SUPV3L1 helicase is critical for cancer suppression

ANIMAL & CELL MODELS

	disruption of the Supv3L1 gene in the mouse has been reported to be embryonic lethal at early developmental stages
	Suv3+/- mice harbored increased mitochondrial DNA (mtDNA) mutations and decreased mtDNA copy numbers, leading to tumor development in various sites and shortened lifespan