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FLASH GENE
Symbol CRP contributors: mct/npt/pgu - updated : 11-02-2019
HGNC name C-reactive protein, pentraxin-related
HGNC id 2367
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in cardiovascular disease
constitutional     --over  
in response to inflammation and is purported to be a risk factor for atherogenesis
constitutional     --over  
in drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome
constitutional     --over  
obstructive sleep apnea syndrome (OSAS)
constitutional     --over  
in a substantial proportion of asymptomatic Hereditary angioedema (HAE) patients and levels of CRP increase significantly during an abdominal attack
Susceptibility
  • to systemic lupus erythematosus (SLE)
  • to cardiovascular disease
  • to variation of CRP level
  • Variant & Polymorphism SNP
  • increasing the risk of systemic lupus erythematosus (SLE)
  • SNP in the promoter increasing the risk of high CRP level and cardiovascular disease
  • individuals homozygous for rs181704186-G have a mean CRP level of 0.23 mg/L, in contrast to individuals heterozygous for rs181704186 with mean CRP of 2.97 mg/L and major allele homozygotes with mean CRP of 4.11 mg/L
  • Candidate gene
    Marker
  • one of the most important biomarker for cardiovascular diseases
  • CRP measurements during the first trimester of pregnancy are helpful in predicting pre-eclampsia
  • high CRP level is significantly associated with higher late mortality in patients with chronic obstructive pulmonary disease (COPD)
  • ADIPOQ/CRP, may be useful for detecting metabolic dysregulation
  • maternal serum and fetal cord CRP levels were higher in the IUGR group (
  • Therapy target
    ANIMAL & CELL MODELS