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FLASH GENE
Symbol ZHX3 contributors: mct/npt - updated : 26-05-2020
HGNC name zinc fingers and homeoboxes 3
HGNC id 15935
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in nephrotic syndrome prior to the onset of proteinuria, and recovery of expression was associated with migration of ZHX3 protein into the nucleus and the development of proteinuria
tumoral     --low  
in clear cell Renal cell carcinoma (RCC), significantly associated with pathological stage
tumoral     --over  
high mRNA levels of ZHX2 and ZHX3 correlated with better overall survival in patients with breast cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • may be useful as an early osteogenic differentiation marker
  • ZHX3 expression may serve as an independent high-risk prognostic predictor
  • Therapy target
    ANIMAL & CELL MODELS