Symbol
| PTK6
| contributors: mct/ - updated : 07-04-2015
|
HGNC name
| PTK6 protein tyrosine kinase 6
|
HGNC id
| 9617
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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tumoral
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|  
| --over
|  
|
in metastatic breast cancer and in breast carcinoma cell lines | tumoral
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|  
|  
| gain of function
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plays a role in cell proliferation and tumorigenesis in breast cancer cells and tissues | tumoral
|  
|  
|  
| gain of function
|
retention of PTK6 in the cytoplasm of prostate cancer cells disrupts its ability to regulate nuclear substrates and leads to aberrant growth | |
Variant & Polymorphism
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| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | endocrine | pancreas | |
may be a novel therapeutic target for pancreatic cancer | cancer | reproductive | prostate | |
in prostate cancer, restoring PTK6 nuclear localization may have therapeutic advantages |
| | | |