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FLASH GENE
Symbol PTK6 contributors: mct/ - updated : 07-04-2015
HGNC name PTK6 protein tyrosine kinase 6
HGNC id 9617
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in metastatic breast cancer and in breast carcinoma cell lines
tumoral       gain of function
plays a role in cell proliferation and tumorigenesis in breast cancer cells and tissues
tumoral       gain of function
retention of PTK6 in the cytoplasm of prostate cancer cells disrupts its ability to regulate nuclear substrates and leads to aberrant growth
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerendocrinepancreas
may be a novel therapeutic target for pancreatic cancer
cancerreproductiveprostate
in prostate cancer, restoring PTK6 nuclear localization may have therapeutic advantages
ANIMAL & CELL MODELS