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FLASH GENE

Symbol

GPER1

contributors: mct/npt/pgu - updated : 10-06-2015

HGNC name	G protein-coupled estrogen receptor 1
HGNC id	4485

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in gastric cancer constitutional     --low   in Goiter tumoral     --over   implicated to associate with the malignant progress of invasive breast cancer (IBC)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast may represent a new target to combat estrogen receptor-positive breast cancer cardiovascular aquired   under cardiac stress exerts direct protection in the heart and may serve as a potential therapeutic target for cardiac drug therapy

ANIMAL & CELL MODELS

Gper deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state