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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

MAPK7

contributors: mct - updated : 31-08-2018

HGNC name	mitogen-activated protein kinase 7
HGNC id	6880

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     in Smith-Magenis syndrome tumoral   amplification     in hepatocellular carcinoma tumoral     --over   might contribute to ovarian cancer metastasis through up-regulating type II collagen expression ( might contribute to ovarian cancer metastasis through up-regulating type II collagen expression

Susceptibility

Variant & Polymorphism other

Candidate gene
Marker	MAPK7 and MAP2K4 could be good markers in assessing response to treatment and development of osteosarcoma
	may be a new prognostic marker in clear cell renal cell carcinoma owing to its relationship with metastasis and more advanced stages
Therapy target
	System Type Disorder Pubmed cancer digestive liver cancer bone   may be a new therapeutic target in invasive osteosarcoma expressing MMP9 diabete type 1   may be a promising target for increasing beta-cell mass in diabetes patients cardiovascular cardiomyopathy   maintenance of cardiac MAPK7 is a therapeutic approach for cardiomyopathy prevention and/or treatment cancer reproductive ovary may be a potential therapeutic target in the clinical treatment for ovarian cancer immunology inflammatory   is a potential therapeutic target in diverse disorders that cause inflammatory critical illness cardiovascular atheroma   Molecules that upregulate ERK5 and its signaling in macrophages may be good drug targets for suppressing cardiovascular diseases

ANIMAL & CELL MODELS

	Erk4-deficient mice are viable and fertile and exhibit no gross morphological or physiological anomalies
	conditional deletion of the erk5 gene in mouse neural stem cells during development reduces the number of GABAergic interneurons in the main olfactory bulb (OB)