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FLASH GENE

Symbol

TNF

contributors: mct/pgu - updated : 24-04-2012

HGNC name	tumor necrosis factor (TNF superfamily, member 2)
HGNC id	11892

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in inflammatory bowel disease constitutional     --over   in DM1 could contribute to the muscle wasting and insulin resistance that are characteristic of myotonic dystrophy constitutional     --over   modulates some catabolic features of TNF in chondrocytes constitutional     --over   in glomerulus and tubule of class III and IV lupus nephritis

Susceptibility

to narcolepsy, cardiac sarcoidosis and systemic juvenile rheumatoid arthritis, vascular dementia and Alzheimer's disease to cerebral malaria, to inflammatory bowel disease (IBD) severe sepsis following burn injury to myasthenia gravis childhood asthma to rheumatoid arthritis to systemic lupus erythematosus

Variant & Polymorphism SNP	a common polymorphism in the promoter region (C->A) associated with reduced circulating levels of TNF308G>A (asthma)-promoter polymorphism-857c in IBD
	SNP associated with severe sepsis following burn injury

Candidate gene
Marker
Therapy target	antibodies specific as therapeutic targets in rheumatoid arthritis
	System Type Disorder Pubmed blood     artificial modulation of TNF production could be a promising therapeutic approach to Fanconi anemia immunology autoimmune articular antibodies specific as therapeutic targets in rheumatoid arthritis

ANIMAL & CELL MODELS