Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TNF contributors: mct/pgu - updated : 24-04-2012
HGNC name tumor necrosis factor (TNF superfamily, member 2)
HGNC id 11892
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in inflammatory bowel disease
constitutional     --over  
in DM1 could contribute to the muscle wasting and insulin resistance that are characteristic of myotonic dystrophy
constitutional     --over  
modulates some catabolic features of TNF in chondrocytes
constitutional     --over  
in glomerulus and tubule of class III and IV lupus nephritis
Susceptibility
  • to narcolepsy, cardiac sarcoidosis and systemic juvenile rheumatoid arthritis,
  • vascular dementia and Alzheimer's disease
  • to cerebral malaria, to inflammatory bowel disease (IBD)
  • severe sepsis following burn injury
  • to myasthenia gravis
  • childhood asthma
  • to rheumatoid arthritis
  • to systemic lupus erythematosus
  • Variant & Polymorphism SNP
  • a common polymorphism in the promoter region (C->A) associated with reduced circulating levels of TNF308G>A (asthma)-promoter polymorphism-857c in IBD
  • SNP associated with severe sepsis following burn injury
  • Candidate gene
    Marker
    Therapy target antibodies specific as therapeutic targets in rheumatoid arthritis
    SystemTypeDisorderPubmed
    blood  
    artificial modulation of TNF production could be a promising therapeutic approach to Fanconi anemia
    immunologyautoimmunearticular
    antibodies specific as therapeutic targets in rheumatoid arthritis
    ANIMAL & CELL MODELS