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FLASH GENE

Symbol

HSPB2

contributors: mct - updated : 12-11-2016

HGNC name	heat shock 27kDa protein 2
HGNC id	5247

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   confers long-lasting neuroprotection against ischemic brain injury via a previously unexplored association and inhibition of MAP3K5 signaling

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	target for interrupting signaling from membrane sex steroid receptors to tumor biology in hormone-responsive cancers )

ANIMAL & CELL MODELS

downregulation of Hspb2 improved the maturation of mouse oocytes, while increased early stage of apoptosis in oocytes by inducing the activation of extrinsic, caspase 8-mediated pathway