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FLASH GENE
Symbol IL10 contributors: mct - updated : 17-11-2017
HGNC name interleukin 10
HGNC id 5962
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation     loss of function
loss of function mutations in interleukin-10 (IL10) and interleukin-10 receptors (IL10R) cause severe infantile (very early onset) inflammatory bowel disease (IBD)
tumoral     --over  
in diffuse large B-cell lymphoma, patients with high serum IL10 had shorter event-free survival (EFS) than patients with low levels
constitutional     --over  
DNA hypomethylation leads to IL10 and IL13 overexpression in systemic lupus erythematosus patients
constitutional     --low  
is associated with risk of Behçet disease (BD)
Susceptibility
  • to hepatocellular carcinoma (HCC)
  • to acute myocardial infarction
  • to Wegener's granulomatosis
  • to sudden infant death with infectious cause
  • to SLE systemic lupus erythematosus
  • to severe malarial anemia
  • to leprosy
  • Variant & Polymorphism SNP , repeat , other
  • CA repeat in IL10 associated with WG
  • IL10 HT2 accelerates progression of chronic hepatitis B virus infection especially to HCC development
  • 1082GG genotype protecting against myocardial infarction
  • CA repeat polymorphism IL-10.G, associated with Wegener's granulomatosis
  • alleles G21/G22 and G21/G23, associated with infectious cause of sudden infant death
  • SNP 819T is associated with leprosy susceptibility
  • haplotypes of IL10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL10 production
  • rs3024505 significantly associated to SLE
  • Candidate gene
    Marker
  • may be a biomarker to identify patients more likely to respond to JAK2-targeted therapy, in diffuse large B-cell lymphoma
  • Therapy target
    ANIMAL & CELL MODELS
  • IL10 deficiency affects the immune functions of dendritic cells, which may contribute to the increased severity of autoimmune diseases seen in IL-10(-/-) mice (