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FLASH GENE
Symbol ZIC1 contributors: mct/pgu - updated : 10-10-2015
HGNC name Zic family member 1 (odd-paired homolog, Drosophila)
HGNC id 12872
ASSOCIATED DISORDERS
corresponding disease(s) DWS1 , CRS12
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
through promoter hypermethylation in gastric cancer
constitutional   deletion    
of ZIC1 and ZIC4 in patient presented with mental retardation, epilepsy, and multiple congenital malformations including spina bifida, mild dysmorphic facial features and Dandy-Walker malformation (
tumoral     --over  
in all five subtypes of liposarcoma compared with normal fat
tumoral     --low  
by hypermethylation may lead to promoter silencing of ZIC1 mRNA and associated with poor survival in hepatocellular carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene for DWS
Marker
  • ZIC1 promoter methylation may serve as a novel non-invasive plasma biomarker for the early detection of gastri cancer
  • Therapy target
  • potential marker for medulloblastoma
  • SystemTypeDisorderPubmed
    cancer  
    targeting ZIC1 or its downstream targets might lead to novel therapy for liposarcoma
    cancerdigestivestomach
    serves as a potential therapeutic target for gastric cancer
    ANIMAL & CELL MODELS
  • loss of Zic1 gene in the mouse causes cerebellar hypoplasia and vertebral defects