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FLASH GENE
Symbol TP73 contributors: mct/npt/pgu - updated : 18-06-2015
HGNC name tumor protein p73
HGNC id 12003
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in bladder carcinoma
tumoral   deletion    
in neuroblastoma in advanced stage
tumoral   amplification    
in neuroblastoma,primary sqamous, primary sqamous cell carcinoma of the lung, head and neck cancer cell line
tumoral   LOH    
in hepatocellular carcinoma
tumoral       loss of function
by abnormal methylation or LOH in non-Hodgkin lymphoma
tumoral     --low  
correlates with increases of SAC protein expression in patients with lung cancer
tumoral     --low gain of function
loss of TAp73 or deltaNp73 up-regulation activates the angiogenic switch that stimulates tumor growth and progression
tumoral     --low  
TP73 methylation is common in patients with myelodysplastic syndromes and is associated with poor prognosis
Susceptibility to cancer
Variant & Polymorphism SNP
  • polymorphism (G4C14-A4T14) probably associates with cancer risk
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Tp73 is a transcriptional activator of Ngfr and Ngfr mRNA and protein levels are strongly reduced in the central and peripheral nervous systems of p73 knockout mice