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FLASH GENE
Symbol GSK3A contributors: mct/shn - updated : 06-03-2019
HGNC name glycogen synthase kinase 3 alpha
HGNC id 4616
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
  • Inhibition of GSK3 in a preclinical murine model of MLL leukaemia provides promising evidence of efficacy and earmarks GSK3 as a candidate cancer drug target
  • ANIMAL & CELL MODELS
  • alterations of GSK3 profoundly affect neuronal morphology in culture
  • knockdown of both GSK3B markedly reduced axon growth in dissociated cultures
  • concomitant loss of Gsk3a and Gsk3b in the oocyte significantly increased neonatal death rate due to congestive heart failure secondary to ventricular hyperplasia
  • dominant-negative GSK-3 Xenopus mutants induced dorsal differentiation, whereas wild-type GSK-3 induced ventralization
  • disruption of the Gsk3a gene in testis results in normal spermatogenesis, but mature sperm present a reduced motility, rendering male mice infertile