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FLASH GENE
Symbol S100A8 contributors: mct - updated : 23-02-2015
HGNC name S100 calcium binding protein A8 (calgranulin A)
HGNC id 10498
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in psoriasis and in epithelial skin tumors
constitutional     --over  
in numerous inflammatory diseases, such as sepsis, rheumatoid arthritis, inflammatory bowel disease, vasculitis and cancer
constitutional     --low  
in placentas of preeclampsia and HELLP syndrome (Buimer 2008)
tumoral     --over  
elevated levels of S100A8 or A9 in the ductal fluid, a near absence of pancreatic enzymes, and high levels of mucins were found to have significantly worse prognosis in pancreatic cancer
constitutional     --over  
overexpression of S100A8-S100A9 in neurons is an early step in oncogenic KRAS-induced gliosis
Susceptibility to rheumatoid arthritis
Variant & Polymorphism
Candidate gene for lipodystrophy and diabetes
Marker
  • S100A8 and S100A9 may serve as biomarkers for the detection of renal cell carcinoma
  • potential marker of disease activity in patients with psoriatic arthritis
  • dysregulated levels of S100A8 gene may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers
  • Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    inhibiting S100A8 and/or S100A9 may be a novel therapy targeting various molecular events involved in the initiation of psoriasis
    cancerurinary 
    attractive anticancer target for therapeutic intervention in kidney cancer
    ANIMAL & CELL MODELS
  • S100a8 (-/-) condition is embryonic lethal