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FLASH GENE
Symbol MEFV contributors: mct/npt - updated : 11-07-2018
HGNC name Mediterranean fever
HGNC id 6998
ASSOCIATED DISORDERS
corresponding disease(s) MEFV
related resource INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
Familial Mediterranean Fever at GeneDis
Susceptibility
  • to Behcet's disease
  • to Fibromyalgia syndrome (FMS)
  • to systemic onset juvenile idiopathic arthritis
  • Variant & Polymorphism other
  • increasing the risk of Behcet's disease
  • heterozygous for rare missense variants of this gene may be predisposed to FMS, possibly triggered by environmental factors (Feng 2009)
  • a significantly higher frequency of MEFV mutations systemic onset juvenile idiopathic arthritis (Ayaz 2009)
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunology  
    the SIVA1-MEFV interaction may be a potential target for future therapeutic strategies
    ANIMAL & CELL MODELS