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FLASH GENE
Symbol FZD5 contributors: mct/npt - updated : 31-03-2017
HGNC name frizzled homolog 5 (Drosophila)
HGNC id 4043
ASSOCIATED DISORDERS
corresponding disease(s) CLBM1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in chronic myelogenous leukemia
constitutional     --over  
during the acquisition of neuronal polarity induces mislocalization of the receptor and a loss of polarized axonal markers
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Fz5(-/-) mice exhibit mild coloboma and microphthalmia at 50p100 of penetrance
  • mutant protein caused coloboma and microphthalmia in zebrafish