Symbol
| ONECUT1
| contributors: mct - updated : 04-01-2023
|
HGNC name
| one cut domain, family member 1
|
HGNC id
| 8138
|
corresponding disease(s)
|
PHGAD
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --low
|  
|
in pancreatic cancer cells | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| ONECUT1 and SOX9 are new biomarkers of acinar-to-ductal metaplasia (ADM) and constitute candidate targets for preventive treatment in cases when ADM may lead to cancer | Therapy target
|
System | Type | Disorder | Pubmed |
digestive | liver | | |
HNF6-mediated pathways represent attractive therapeutic targets for the treatment of the relative diseases such as cholestasis |
| | |
| mice deficient in ONECUT1, ONECUT2, or both exhibit depleted levels of F9 |