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FLASH GENE
Symbol ONECUT1 contributors: mct - updated : 04-01-2023
HGNC name one cut domain, family member 1
HGNC id 8138
ASSOCIATED DISORDERS
corresponding disease(s) PHGAD
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in pancreatic cancer cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • ONECUT1 and SOX9 are new biomarkers of acinar-to-ductal metaplasia (ADM) and constitute candidate targets for preventive treatment in cases when ADM may lead to cancer
  • Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    HNF6-mediated pathways represent attractive therapeutic targets for the treatment of the relative diseases such as cholestasis
    ANIMAL & CELL MODELS
  • mice deficient in ONECUT1, ONECUT2, or both exhibit depleted levels of F9