Symbol
| PEA15
| contributors: mct/npt/shn - updated : 25/12/2010
|
HGNC name
| phosphoprotein enriched in astrocytes 15
|
HGNC id
| 8822
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in some breast cancer lines | constitutional
|  
|  
| --over
|  
|
induces a marked resistance against glucose deprivation-induced apoptosis | constitutional
|  
|  
| --over
|  
|
overexpression represents a common defect in first-degre relatives of patients with type 2 diabetes and is correlated with reduced insulin sensitivity | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
| | | |
| PEA-15 expression increases astrocyte survival after exposure to TNF in PEA-15 null mutant mice |