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FLASH GENE
Symbol PEA15 contributors: mct/npt/shn - updated : 25/12/2010
HGNC name phosphoprotein enriched in astrocytes 15
HGNC id 8822
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in some breast cancer lines
constitutional     --over  
induces a marked resistance against glucose deprivation-induced apoptosis
constitutional     --over  
overexpression represents a common defect in first-degre relatives of patients with type 2 diabetes and is correlated with reduced insulin sensitivity
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • PEA-15 expression increases astrocyte survival after exposure to TNF in PEA-15 null mutant mice