Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAGEA3 contributors: mct/npt - updated : 08-12-2009
HGNC name melanoma antigen family A, 3
HGNC id 6801
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast cancer, melanoma, advanced gastric carcinomas and hepatocellular carcinomas, squamous cell carcinoma of head and neck, malignant myeloma
constitutional     --low  
results in Tp53 transcriptional induction, also through reciprocal histone acetylation and methylation modifications (Zhu 2008)
tumoral     --over  
by promoter hypomethylation up-regulates its expression in colorectal carcinomas as well as in gastric cancers and might play a significant role in the development and progression of colorectal carcinomas (Kim 2006)
Susceptibility
Variant & Polymorphism
Candidate gene aberrant methylation patterns of MAGEs CpG islands using methylation-special PCRs may be useful for diagnosis of hepatocellular carcinoma
Marker
Therapy target
ANIMAL & CELL MODELS