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FLASH GENE

Symbol

NFE2L1

contributors: mct/shn - updated : 07-03-2015

HGNC name	nuclear factor (erythroid-derived 2)-like 1
HGNC id	7781

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function NFE2L1 deficiency leads to the reduced expression of the transcriptional coactivator genes LPIN1 and PPARGC1B

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     NFE2L1-mediated proteasome homeostasis could be an attractive target for therapeutic intervention in cancer

ANIMAL & CELL MODELS

	disruption of the transcription factor Nrf-1 results in anemia and embryonic lethality in mice
	mice with somatic inactivation of nrf1 in the liver develop hepatic cancer whose livers exhibit steatosis, apoptosis, necrosis, inflammation, and fibrosis