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FLASH GENE
Symbol NFE2L1 contributors: mct/shn - updated : 07-03-2015
HGNC name nuclear factor (erythroid-derived 2)-like 1
HGNC id 7781
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
NFE2L1 deficiency leads to the reduced expression of the transcriptional coactivator genes LPIN1 and PPARGC1B
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
NFE2L1-mediated proteasome homeostasis could be an attractive target for therapeutic intervention in cancer
ANIMAL & CELL MODELS
  • disruption of the transcription factor Nrf-1 results in anemia and embryonic lethality in mice
  • mice with somatic inactivation of nrf1 in the liver develop hepatic cancer whose livers exhibit steatosis, apoptosis, necrosis, inflammation, and fibrosis