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FLASH GENE

Symbol

MAGEA1

contributors: mct/npt - updated : 06-04-2020

HGNC name	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
HGNC id	6796

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in primary breast tumor in progression, and in hepatocellular carcinoma tumoral     --other   dysregulation of expression in hematological malignanciesnot determined solely by the methylation status of the promoter region (in multiple myeloma) tumoral     --over   by promoter hypomethylation up-regulates its expression in colorectal carcinomas as well as in gastric cancers and might play a significant role in the development and progression of colorectal carcinomas (Kim 2006) tumoral     --other   MAGEA1 expression is associated with good prognosis in neuroblastoma (Grau 2009) tumoral     --over   GPC3, MAGE1A and MAGEA3 were increased with advanced tumor stage, size, and nodule numbers in Hepatocellular Carcinoma tumoral     --other   expressed in 93p100 endometrioid endometrial cancer grade 3 and 86p100 of serous and clear cell carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene	aberrant methylation patterns of MAGEs CpG islands using methylation-special PCRs may be useful for diagnosis of hepatocellular carcinoma
Marker	expression of MAGEA1 genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer
Therapy target
	System Type Disorder Pubmed cancer reproductive breast novel target in breast cancer clinical treatment cancer skin   MAGEA1 may be a potential therapeutic target for melanoma patients

ANIMAL & CELL MODELS