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FLASH GENE
Symbol XCL1 contributors: mct/npt - updated : 07-01-2013
HGNC name chemokine (C motif) ligand 1
HGNC id 10645
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in CD4+ and CD8+ T cells in Wegener granulomatosis
constitutional     --low  
associated with the suboptimal regulatory function of Treg in allergic asthma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • thymocytes from XCL1-deficient mice elicit dacryoadenitis in nude mice
  • Xcl1-deficient mice are defective in the medullary accumulation of thymic dendritic cells and the thymic generation of naturally occurring regulatory T cells (nT reg cells)