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FLASH GENE
Symbol CX3CL1 contributors: mct/npt/pgu - updated : 28-09-2020
HGNC name chemokine (C-X3-C motif) ligand 1
HGNC id 10647
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in airway smooth muscle, lung endothelium and epithelium upon allergen challenge, in people with asthma
constitutional     --over  
increased in patients with chronic heart failure, in accordance with disease severity
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
allergyasthm 
CX3CR1 and CX3CL1 may represent attractive therapeutic targets in asthma
cancermetastases 
CX3CL1-CX3CR1 axis may be a novel target for the therapeutic intervention of bone resorbing diseases such as cancer bone metastasis
osteoarticularboneostéoporosis
CX3CL1-CX3CR1 axis may be a novel target for the therapeutic intervention of bone resorbing diseases such as rheumatoid arthritis, osteoporosis
neurologyneurodegenerative 
CX3CL1/CX3CR1 communication system is a therapeutic target for amyotrophic lateral sclerosis (ALS)patients
neurosensorialvisualdegenerative
CX3CL1-CX3CR1 signaling is a molecular mechanism capable of modulating microglial-mediated degeneration and represents a potential molecular target in therapeutic approaches to RP
ANIMAL & CELL MODELS