Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
|  
| loss of function
|
in polycystic kidney disease by inhibition of renal ciliogenesis | constitutional
|  
| deletion
|  
|  
|
in ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting | tumoral
|  
|  
| --over
|  
|
in the majority of human prostate cancer cell lines and primary tumor biopsies | constitutional
|  
| deletion
|  
|  
|
selective deletion of KIF3A in osteoblasts disrupts primary cilia formation and/or function and impairs osteoblast-mediated bone formation through multiple pathways including intracellular calcium, hedgehog and Wnt signaling | |