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FLASH GENE
Symbol YY1 contributors: mct - updated : 10-04-2018
HGNC name YY1 transcription factor
HGNC id 12856
ASSOCIATED DISORDERS
corresponding disease(s) MRFFE
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in osteosarcoma cells plays a key role in positive regulation of PRDM2
tumoral fusion      
with EWSR1 genes in mesothelioma with t(14;22)(q32;q12)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the immunoglobulin heavy-chain (IgH) locus and a block in the progenitor-B-to-precursor-B-cell transition, which was partially rescued by a prerearranged IgH transgene