Symbol
| HSF1
| contributors: mct/pgu - updated : 19-01-2016
|
HGNC name
| heat shock transcription factor 1
|
HGNC id
| 5224
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in prostate carcinoma | tumoral
|  
|  
| --over
|  
|
in multiple myeloma | tumoral
|  
|  
| --over
|  
|
is associated with reduced breast cancer survival, particularly among those with ESR1-positive disease ( | tumoral
|  
|  
|  
| gain of function
|
in metastatic and highly tumorigenic human mammary epithelial cell lines | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| high expression of HSF1-cancer signature had a remarkable correlation with poor prognosis | Therapy target
|
System | Type | Disorder | Pubmed |
cancer | | | |
therapeutic role for HSF1 inhibitors in cancers | cancer | hemopathy | | |
inhibition of HSF1 affects multiple protective HSPs and might therefore represent a therapeutic strategy - in particular in combination with proteasome or HSP90 inhibitors
| cancer | reproductive | breast | |
drugs that specifically target HSF1 function and ongoing work to develop inhibitors of HSP90 and other downstream pathways regulated by HSF1 are potential therapy in breast cancer |
| | |
| balance between the cell survival and death signals mediated by Hsp70 and Tdag51, respectively, may be disturbed by the altered expression of Hsf1 during the progression of disease in an ALS model |