Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HSF1 contributors: mct/pgu - updated : 19-01-2016
HGNC name heat shock transcription factor 1
HGNC id 5224
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in prostate carcinoma
tumoral     --over  
in multiple myeloma
tumoral     --over  
is associated with reduced breast cancer survival, particularly among those with ESR1-positive disease (
tumoral       gain of function
in metastatic and highly tumorigenic human mammary epithelial cell lines
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • high expression of HSF1-cancer signature had a remarkable correlation with poor prognosis
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    therapeutic role for HSF1 inhibitors in cancers
    cancerhemopathy 
    inhibition of HSF1 affects multiple protective HSPs and might therefore represent a therapeutic strategy - in particular in combination with proteasome or HSP90 inhibitors
    cancerreproductivebreast
    drugs that specifically target HSF1 function and ongoing work to develop inhibitors of HSP90 and other downstream pathways regulated by HSF1 are potential therapy in breast cancer
    ANIMAL & CELL MODELS
  • balance between the cell survival and death signals mediated by Hsp70 and Tdag51, respectively, may be disturbed by the altered expression of Hsf1 during the progression of disease in an ALS model