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FLASH GENE
Symbol CTTN contributors: shn/mct - updated : 10-09-2015
HGNC name cortactin
HGNC id 3338
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast cancer with poor prognosis, in cell lines from breast and squamous carcinomas of head and neck
tumoral   amplification    
coamplified with CCND1 in oral squamous cell carcinoma
tumoral     --over  
is closely associated with hepatocellular carcinoma poor prognosis that caused by cancer embolus and metastasis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
tumor  
EGFR-independent role of cortactin in HNSCC (squamous carcinomas of head and neck) may have important implications regarding the design of targeted therapies to combat tumor spread
ANIMAL & CELL MODELS