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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

ACACB

contributors: mct/npt/shn - updated : 07-06-2016

HGNC name	acetyl-CoA carboxylase beta
HGNC id	85

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     Cardiac-specific deletion of ACACB prevents metabolic remodeling during pressure-overload hypertrophy

Susceptibility

to obesity and diabetes

Variant & Polymorphism

Candidate gene
Marker
Therapy target	therapeutic target for obesity and diabetes (Cho 2010)

ANIMAL & CELL MODELS

Acc2-/- mutant mice have a normal life span, a higher fatty acid oxidation rate, and lower amounts of fat