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FLASH GENE
Symbol ACACB contributors: mct/npt/shn - updated : 07-06-2016
HGNC name acetyl-CoA carboxylase beta
HGNC id 85
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional   deletion    
Cardiac-specific deletion of ACACB prevents metabolic remodeling during pressure-overload hypertrophy
Susceptibility to obesity and diabetes
Variant & Polymorphism
Candidate gene
Marker
Therapy target therapeutic target for obesity and diabetes (Cho 2010)
ANIMAL & CELL MODELS
  • Acc2-/- mutant mice have a normal life span, a higher fatty acid oxidation rate, and lower amounts of fat