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Symbol SFRP1 contributors: mct/shn/pgu - updated : 12-12-2018
HGNC name secreted frizzled-related protein 1
HGNC id 10776
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in breast carcinoma (expression was inversely correlated with tumor stage but not with tumor grade or lymph node status
tumoral       loss of function
by hypermethylation in colorectal cancer and in ovarian cancers
tumoral       loss of function
by hypermethylation in non-small-cell lung cancer (NSCLC)
tumoral       loss of function
by promoter hypermethylation, predominant mechanism of SFRP1 gene silencing in breast cancer and is associated with unfavourable prognosis
tumoral     --low  
in transitional cell carcinomas of the bladder
tumoral     --low  
silencing leads to oncogenic activation of the Wnt pathway and contributes to cervical cancer progression through the epithelial mesenchymal transition program
tumoral     --low  
markedly reduced in both the breast cancer cell lines and primary tumour specimens relative to normal primary mammary epithelial cells even when SFRP1 is amplified
tumoral     --low  
by hypermethylation in primary hepatocellular carcinoma
tumoral     --low  
methylation-associated silencing of SFRP1 frequently occurs in renal cell carcinoma and plays a pivotal role in early carcinogenesis
tumoral     --low  
by promoter methylation frequently found in renal cell carcinoma
constitutional       loss of function
of SFRP1 and SFRP2, two postulated Wnt antagonists, perturbs retinal neurogenesis
constitutional     --low  
by hypermethylation in keloid tissues, compared with that in normal skin tissues
tumoral     --low  
decreased markedly in patients with acute myeloid leukemia (AML) compared to controls
constitutional     --low  
of SFRP1 may contribute to the pathogenesis of IUGR placental dysfunction, whereas the loss of the protein may be involved in the development of human trophoblastic tumors
Variant & Polymorphism
Candidate gene
Therapy target
might be a therapeutic target for keloid treatment
  • in postnatal Sfrp1-/- animals the anterior hippocampus is reduced and the neocortex is shorter in the antero-posterior and medio-lateral axis but is thicker
  • loss of Sfrp1 exacerbates weight gain, glucose homeostasis and inflammation in mice in response to diet induced obesity