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FLASH GENE
Symbol AGTR2 contributors: mct - updated : 06-04-2020
HGNC name angiotensin II receptor, type 2
HGNC id 338
ASSOCIATED DISORDERS
corresponding disease(s) MRX88
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
in mental retardation
constitutional     --over  
reduces enhanced collagen accumulation, MMP expression and activity in atherosclerotic regions via inhibition of pro-oxidant signals
constitutional     --over  
moderate cardiac-selective overexpression of AGTR2 protects heart function from ischaemic injury, which may be mediated, at least in part, through modulation of components of the cardiac renin-angiotensin system and collagen levels in the myocardium
constitutional   deletion    
in blood cells has a harmful effect on ischemic brain injury
constitutional     --over  
represents an endogenous protective pathway against vascular calcificationand its stimulation may efficiently reduce adverse cardiovascular events in patients with chronic kidney disease
constitutional     --other  
altered expression of AGTR1 and AGTR2 with aging may induce mitochondrial dysfunction, the main risk factor for neurodegeneration
Susceptibility to preeclampsia
Variant & Polymorphism
  • increasing the risk of preeclampsia
  • gender-specific association between AGTR2 polymorphism, kidney function and premature aging of the arterial tree in patients with type I diabetes
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 1 
    targeted AGTR2 overexpression in renal cells may open new avenues to develop novel types of drugs preventing diabetic nephropathy
    miscelleaneouspain 
    AGTR2 antagonist showed effective analgesia for neuropathic pain
    immunologyinflammatory 
    AT2R agonism might represent a novel therapeutic strategy for patients with rheumatoid arthritis
    cancerurinary 
    is a promising novel target gene for Bldder cancer gene therapy
    psychiatry  
    AGTR2 stimulation may be a new therapeutic approach to improve eating disorder associated with dopamine resistance
    ANIMAL & CELL MODELS
  • deletion of Agtr2 accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling
  • in female mice via potentially regulating estrogen may have protective role against Body weight gain and impaired glucose tolerance and lipid metabolism