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FLASH GENE
Symbol GRIA3 contributors: mct/pgu - updated : 13-11-2013
HGNC name glutamate receptor, ionotrophic, AMPA 3
HGNC id 4573
ASSOCIATED DISORDERS
corresponding disease(s) MRXS29
Susceptibility
  • to schizophrenia among females but not in males
  • to migraine with aura
  • Variant & Polymorphism other
  • carriers of rs1034428 A allele have a 2.19-fold higher risk of developing schizophrenia compared to non-carriers and 3.28-fold higher risk for developing a non-paranoid phenotype
  • GRIA3 (rs3761555) genes strongly associated with migraine with aura
  • Candidate gene
  • for X-linked mental retardation (severely reduced GRIA3 expression results in mental retardation)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking GluA1 showed a reduced anxiety and male aggression.