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FLASH GENE
Symbol PDHA1 contributors: mct/npt - updated : 06-07-2022
HGNC name pyruvate dehydrogenase (lipoamide) alpha 1
HGNC id 8806
ASSOCIATED DISORDERS
corresponding disease(s) PDHA1D , LGS
related resource MITOP database
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
promotes cancer progression and acts as a poor prognostic factor for cancer
tumoral     --low  
significantly correlated with a poorer overall survival in patients with Gastric cancer
constitutional     --low  
significantly decreased in the putamen and substantia nigra of patients with idiopathic Parkinson disease
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • decreased expression of PDHA1 might be an independent prognostic factor in unfavorable outcomes in ovarian carcinoma
  • PDHA1 is an independent predictor of overall survival in Gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS