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FLASH GENE
Symbol OTC contributors: mct - updated : 29-04-2013
HGNC name ornithine carbamoyltransferase
HGNC id 8512
ASSOCIATED DISORDERS
corresponding disease(s) OTC
related resource Ornithine transcarbamylase deficiency
Susceptibility to alzheimer disease (AD)
Variant & Polymorphism SNP
  • two SNPs -389 G/A (rs5963409) and -241 A/G (rs5963411) located in the promoter of the OTC gene are associated with the risk of developing AD
  • Candidate gene
    Marker
  • appeared superior to cytosol-derived markers in the detection of alcohol-induced liver injury
  • Therapy target
    ANIMAL & CELL MODELS