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FLASH GENE
Symbol CTSB contributors: mct/npt/pgu - updated : 04-06-2016
HGNC name cathepsin B
HGNC id 2527
ASSOCIATED DISORDERS
corresponding disease(s) KWE
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in amyotrophic lateral sclerosis
tumoral     --over  
in malignant anaplastic astrocytomas and glioblastomas
Susceptibility to osteoarthritis
Variant & Polymorphism other overexpression of truncated form (lacking exons 2 and 3) in osteoarthritic cartilage
Candidate gene
Marker
  • might serve as a prognostic and therapeutic marker for lung squamous cell carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    with its substrate BID were shown to be molecular links between apoptosis and autophagy in breast cancer MCF-7 cells exposed to the cytostatic drug, camptothecin
    metabolismlysosome 
    targeting CTSB may be of relevance in the treatment of liver fibrosis in patients with Niemann-Pick disease
    cancerreproductiveuterus
    potential to provide a new therapeutic target for treating endometrial malignancy
    miscelleaneouspain 
    CTSB-specific inhibitors may represent a useful new strategy for treating inflammation-associated pain
    cancermetastases 
    therapeutic benefits of its selective inhibition in bone metastasis in breast cancer
    ANIMAL & CELL MODELS