Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol C5 contributors: mct/npt - updated : 02-05-2013
HGNC name complement component 5
HGNC id 1331
ASSOCIATED DISORDERS
corresponding disease(s) C5
related resource C5base - Mutation registry for C5 deficiency
Susceptibility
  • to hepatic fibrosis
  • to rheumatoid arthritis
  • to adverse cardiovascular outcome in male patients with carotid atherosclerosis
  • Variant & Polymorphism other
  • a common genetic variant at the TRAF1-C5 locus is associated with an increased risk of anti-CCP-positive rheumatoid arthritis (Plenge 2007)
  • C5 rs17611 GG genotype is associated with increased C5a plasma levels and represents a risk factor for adverse cardiovascular outcome in male patients with carotid atherosclerosis
  • Candidate gene
    Marker
  • C5 fragment levels in cerebrospinal fluid (CSF) of patients with bacterial meningitis correlated with several clinical indicators of poor prognosis
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    C5-specific monoclonal antibodies could be a promising new antiinflammatory adjuvant therapy for pneumococcal meningitis
    ANIMAL & CELL MODELS
  • C5a receptor-deficient mice with pneumococcal meningitis had lower CSF wbc counts and decreased brain damage compared with WT mice